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Computational Biology, Data Scientist
Stefano Pirro
,
London, United Kingdom
Experience
Other titles
Skills
I'm offering
I have a Bachelor’s Degree in Biotechnology, a Master Degree in Bioinformatics and a PhD in Bioinformatics.
I have an excellent experience in:
- Next Generation Sequencing (NGS) data analysis
- Mass Cytometry (CyTOF) data analysis
- General statistics and data visualisation
- Machine learning (supervised and unsupervised)
- Regression models (linear and non-linear)
- Creation of biological databases
- Custom scripting (python, R)
I have an excellent experience in:
- Next Generation Sequencing (NGS) data analysis
- Mass Cytometry (CyTOF) data analysis
- General statistics and data visualisation
- Machine learning (supervised and unsupervised)
- Regression models (linear and non-linear)
- Creation of biological databases
- Custom scripting (python, R)
Markets
United Kingdom
Links for more
Once you have created a company account and a job, you can access the profiles links.
Language
English
Fluently
French
Good
Italian
Fluently
Ready for
Ongoing relation / part-time
Available
My experience
2019 - ?
job
Postdoctoral Research Assistant
UCL Cancer Institute.
Leading a bioinformatics project for the high-sensitive
detection of tumour content, starting from methylation
levels of plasma-derived ctDNA
detection of tumour content, starting from methylation
levels of plasma-derived ctDNA
Research, Content, Bioinformatics
2014 - ?
job
Co-founder and Bioinformatics director
MirNat s.r.l.
- Maintenance of all bioinformatics products
- Development of new tools
- Leading the bioinformatics part of research projects
focused on the sequencing of miRNAs from dietary
plants and the identification of ones with an active
role in the regulation of human genes.
- Development of new tools
- Leading the bioinformatics part of research projects
focused on the sequencing of miRNAs from dietary
plants and the identification of ones with an active
role in the regulation of human genes.
Research, Bioinformatics, Development, Founder
2018 - 2019
job
Postdoctoral Research Assistant
Barts Cancer Institute.
Leading the development and maintenance of the Pancreas Expression Database
(http://www.analytics.pancreasexpression.org).
The main tasks are:
• Integration of genomics and transcriptomics data
from several data sources (TCGA, ICGC, CCLE, Genie, PubMed)
• Optimisation of current analysis and development of new ones.
- Leading the bioinformatics part of a research project
focused on tracking the somatic alterations in blood-
derived ctDNAs extracted from PDAC patients, across
different time points. The main aim of the study is to identify a "genomic fingerprint" that may act as
biomarker for the early detection of the pancreatic
cancer. The study is currently involving 11 patients with a
total of almost 50 WGS data sets. I developed a pipeline for the detection and analysis of somatic gene variants
(SNPs and Indels) of ctDNA derived from patients affected
by pancreatic cancer. The pipeline can be obviously
applied to any other cancer by proper tuning. I also
collaborate with the wet-lab scientists in the group for the experimental validation of detected mutations, by taking
advantage of the ddPCR technology.
- Development of a bioinformatics method for the stratification of cancer patients by a network-based
approach. The method is able to quantify the
perturbation rate of several key-pathways, calculate the
"distance" with the wild-type condition and then take
advantage of these metrics to perform a clustering of the patients.
(http://www.analytics.pancreasexpression.org).
The main tasks are:
• Integration of genomics and transcriptomics data
from several data sources (TCGA, ICGC, CCLE, Genie, PubMed)
• Optimisation of current analysis and development of new ones.
- Leading the bioinformatics part of a research project
focused on tracking the somatic alterations in blood-
derived ctDNAs extracted from PDAC patients, across
different time points. The main aim of the study is to identify a "genomic fingerprint" that may act as
biomarker for the early detection of the pancreatic
cancer. The study is currently involving 11 patients with a
total of almost 50 WGS data sets. I developed a pipeline for the detection and analysis of somatic gene variants
(SNPs and Indels) of ctDNA derived from patients affected
by pancreatic cancer. The pipeline can be obviously
applied to any other cancer by proper tuning. I also
collaborate with the wet-lab scientists in the group for the experimental validation of detected mutations, by taking
advantage of the ddPCR technology.
- Development of a bioinformatics method for the stratification of cancer patients by a network-based
approach. The method is able to quantify the
perturbation rate of several key-pathways, calculate the
"distance" with the wild-type condition and then take
advantage of these metrics to perform a clustering of the patients.
Research, Database, Optimization, Integration, Analytics, Technology, Network, Bioinformatics, Development, Http, Tuning
2006 - 2010
job
Computer Programmer
PS Mutui s.r.l.
- Development of a financial software, the "GesPra"
- Maintenance of the company website
- Technical support
- Maintenance of the company website
- Technical support
Website, Support, Development, Software
2008 - 2009
job
Webmaster and techical assistant
Lay Grafica s.s.
Development and maintenance of several
websites
websites
Websites, Webmaster, Development
My education
2013
-
2016
University of Rome Tor Vergata
Doctorate, Cellular and Molecular Biology
Doctorate, Cellular and Molecular Biology
2010
-
2012
University of Rome Tor Vergata
Masters, NATIONALITY
Masters, NATIONALITY
2006
-
2010
University of Rome Tor Vergata
Bachelors, French
Bachelors, French
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